Reverse Engineering of Genetic Networks
نویسندگان
چکیده
Many biologists believe that biological experimental techniques using gene expression with micro array enable to discover the structure and function of genetic networks in cells. Recent study interest is to use the results of the techniques and infer the biological facts such as signal pathways. In this paper, I present and compare several methodologies to explore and reconstruct genetic networks. Many approaches are applied and compared to three different data sets: synthetic data generated from GeneNetSim, diffuse large B cell lymphoma gene expression data and gene expression data in Arabidopsis thaliana plants. I found that genes with transcription function act as hubs in biological networks in Arabidopsis thaliana plant. Finally, I built a genetic network for Arabidopsis thaliana.
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